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ISSN: 0300-9041
ISSNe: 2594-2034


Indizada en: SciELO, Índice Médico Latinoamericano, LILACS, Medline
Editada por la Federación Mexicana de Colegios de Obstetricia, y Ginecologia AC
Fundada por la Asociación Mexicana de Ginecología y Obstetricia en 1945
 

INFORMACIÓN EXCLUSIVA PARA LOS PROFESIONALES DE LA SALUD


Periodicidad: continua
Abreviatura: Ginecol Obstet Mex
ISSN: 0300-9041
ISSNe: 2594-2034
Indizada en: Scimago, Índice Médico Latinoamericano, Lilacs, Medline, Science Citation Index, Ulrich, Ebsco.

Concentraciones de vitamina D en mujeres embarazadas y su relación con diabetes gestacional

Vitamin D levels in pregnant women and their relationship with gestational diabetes.

Ginecol Obstet Mex. 2020; 88 (12): 853-859.

https://doi.org/10.24245/gom.v88i12.4592

Alonso Antonio Collantes-Gutiérrez,1 Teresita Romero-Ogawa,2 Alejandro Morales-López,3 Irene Aurora Espinosa-de Santillana4

1 Adscrito al servicio de Ginecología y Obstetricia.
2 Docente investigadora, Facultad de Medicina.
3 Jefe del servicio de Ginecología y Obstetricia.
4 Docente investigadora de tiempo completo, Facultad de Estomatología.
Hospital Universitario, Benemérita Universidad Autónoma de Puebla, Puebla.


Corrrespondencia:

Alonso Antonio Collantes Gutiérrez
alonso.collantesg@correo.buap.mx

Debe citarse como:

Collantes-Gutiérrez AA, Romero-Ogawa T, Morales-López A, Espinosa-de Santillana IA. Concentraciones de vitamina D en mujeres embarazadas y su relación con diabetes gestacional. Ginecol Obstet Mex. 2020; 88 (12): 853-859. https://doi.org/10.24245/gom.v88i12.4592

Resumen

OBJETIVO: Comparar las concentraciones de vitamina D en pacientes embarazadas sanas vs con diabetes gestacional, en un hospital de Puebla, México.

MATERIALES Y MÉTODOS: Estudio prospectivo, de casos y controles, en el que se compararon las concentraciones de vitamina D en pacientes embarazadas con diabetes gestacional, y como grupo control embarazadas sanas, pareadas por edad e IMC, que acudieron a control prenatal a la consulta externa del servicio de Ginecología del Hospital Universitario de Puebla.

RESULTADOS: Se estudiaron 25 pacientes con diabetes gestacional y 25 sin esta enfermedad. La deficiencia de vitamina D coexistió en 30% de las pacientes y 44% denotó insuficiencia de dicha vitamina, independientemente del diagnóstico de diabetes gestacional. Las concentraciones de vitamina D entre las embarazadas con diabetes gestacional (23.29 ±9.00 ng/mL) y las embarazadas sin diabetes (26.76 ±9.33 ng/mL), no denotaron diferencia significativa (p = 0.14). La razón de posibilidades demostró que no existe asociación entre la diabetes gestacional y la deficiencia de vitamina D; RM = 1.882 (IC95%: 0.518-6.845; p = 0.333).

CONCLUSIONES: En este estudio las concentraciones de vitamina D no se relacionaron con la diabetes gestacional. Las embarazadas tuvieron porcentajes altos de deficiencia e insuficiencia de vitamina D.

PALABRAS CLAVE: Diabetes mellitus gestacional; 25-hidroxivitamina D; vitamina D; deficiencia de vitamina D; embarazo.

Abstract

OBJECTIVE: Contrast the levels of vitamin D, in pregnant woman with and without gestational diabetes.

MATERIALS AND METHODS: This was an prospective, case control study, were we compared vitamin D levels between two groups, 25 pregnant women with gestational diabetes and, paired by age and IMC, with 25 healthy pregnant control women, who attended to prenatal care, in the department of Gynecology and Obstetrics in the Hospital Universitario de Puebla.

RESULTS: Regardless of gestational diabetes, vitamin D deficiency was in 30% patients, and vitamin D insufficiency in the 44%. The vitamin D levels between the patients with gestational diabetes (23.29 ± 9.00 ng/mL) and the healthy patients (26.76 ± 9.33 ng/mL), didn’t show significant difference (p = 0.14). This study didn’t show association between gestational diabetes and vitamin D deficiency OR = 1.882 (IC95%: 0.518-6.845; p = 0.333).

CONCLUSIONS: Vitamin D levels didn’t relate to gestational diabetes. Pregnant women had high percentages of vitamin D deficiency and insufficiency.

KEYWORDS: Diabetes, Pregnancy-Induced, Diabetes Mellitus, Gestational; Gestational Diabetes; 25-Hidroxy Vitamin D; Deficiency; Vitamin D3; Pregnancy.

    1. American Diabetes Association. Classification and diagnosis of diabetes. Diabetes Care. 2017; 40. doi.10.2337/dc17-S005
    2. Instituto Mexicano del Seguro Social. Diagnóstico y tratamiento de la diabetes en el embarazo. 2016:1-68. http://www.imss.gob.mx/sites/all/statics/guiasclinicas/320GER.pdf.
    3. Bello-Chavolla OY, et al. Epidemiology of diabetes mellitus in Mexico. Nutr Rev. 2017; 75: 4-12. doi.10.1093/nutrit/nuw030
    4. Serrano Berrones MA. Incidencia de diabetes gestacional en el Hospital Regional Adolfo López Mateos mediante la prueba de O´Sullivan. Rev Esp Méd Quir. 2013; 18: 287-91.
    5. Ramírez-Torres MA. The importance of gestational diabetes beyond pregnancy. Nutr Rev. 2013; 71 (Suppl 1): 37-41. doi.10.1111/nure.12070
    6. Savitz DA, et al. Ethnicity and gestational diabetes in New York City, 1995-2003. BJOG An Int J Obstet Gynaecol. 2008; 115 (8): 969-78. doi.10.1111/j.1471-0528.2008.01763.x
    7. Mousa A, et al. Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin. Mol Nutr Food Res. 2017:1700488. doi.10.1002/mnfr.201700488
    8. Pons R, et al. Risk factors for gestational diabetes mellitus in a sample of pregnant women diagnosed with the disease. Diabetol Metab Syndr. 2015; 7 (Suppl 1): A80. doi.10.1186/1758-5996-7-S1-A80
    9. Huerta-Chagoya A, et al. Genetic determinants for gestational diabetes mellitus and related metabolic traits in mexican women. PLoS One. 2015; 10 (5): 1-17. doi.10.5061/dryad.kq0k2.The
    10. Amraei M, et al. Effects of vitamin d deficiency on incidence risk of gestational diabetes mellitus: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2018; 9: 7. doi.10.3389/fendo.2018.00007
    11. Al-Shaikh GK, et al. Impact of vitamin D deficiency on maternal and birth outcomes in the Saudi population: A cross-sectional study. BMC Pregnancy Childbirth. 2016; 16 (1): 1-9. doi.10.1186/s12884-016-0901-4
    12. Dovnik A, Mujezinović F. The association of vitamin D levels with common pregnancy complications. Nutrients. 2018; 10 (7): 867. doi.10.3390/nu10070867
    13. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014; 21 (3): 319-29. doi.10.1016/j.chembiol.2013.12.016
    14. Triunfo S, et al. Low maternal circulating levels of vitamin D as potential determinant in the development of gestational diabetes mellitus. J Endocrinol Invest. 2017; 40 (10): 1049-59. doi.10.1007/s40618-017-0696-9
    15. González-Parra E, Egido J. Vitamina D, síndrome metabólico y diabetes mellitus. Med Clin (Barc). 2014; 142 (11): 493-96. doi.10.1016/j.medcli.2014.01.024
    16. Zhang Y, et al. Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect. BJOG An Int J Obstet Gynaecol. 2018; 125 (7): 784-93. doi.10.1111/1471-0528.15060
    17. Aghajafari F, et al. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ 2013; 346: f1169. doi.10.1136/bmj.f1169
    18. Dabelea D, et al. Increasing prevalence of gestational diabetes mellitus (GDM) over time and by birth cohort: Kaiser Permanente of Colorado GDM screening program. Diabetes Care. 2005; 28 (3): 579-84. doi.10.2337/diacare.28.3.579
    19. Bener A, et al. Prevalence of gestational diabetes and associated maternal and neonatal complications in a fast-developing community: global comparisons. Int J Womens Health. 2011; 3: 367-73. doi.10.2147/IJWH.S26094
    20. Shamah-Levy T, et al. Overweight and obesity in Mexican vulnerable population. Results of Ensanut 100k. Salud Publica Mex. 2019; 61 (6): 852-65. doi.10.21149/10585
    21. Medina C, et al. Evidence of increasing sedentarism in Mexico City during the last decade: Sitting time prevalence, trends, and associations with obesity and diabetes. PLoS One. 2017; 12 (12). doi.10.1371/journal.pone.0188518
    22. Dodds L, et al. Vitamin D status and gestational diabetes: Effect of smoking status during pregnancy. Paediatr Perinat Epidemiol. 2016; 30 (3): 229-37. doi.10.1111/ppe.12278
    23. De-Regil LM, et al. Vitamin D supplementation for women during pregnancy. Sao Paulo Med J. 2016; 134 (3): 274-75. doi.10.1590/1516-3180.20161343T2
    24. Holick MF, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 1911; 96 (7): 1911-30. doi.10.1210/jc.2011-0385
    25. Rodriguez A, et al. Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes. BJOG An Int J Obstet Gynaecol. 2015; 122 (12): 1695-704. doi.10.1111/1471-0528.13074
    26. Fard BB. Comparison of vitamin D level in pregnant women with and without gestational diabetes. Rev Latinoam Hipertens. 2020; 15: 33-35. www.revhipertension.com.
    27. Camarena-Pulido EE, et al. Concentraciones de 25-hidroxivitamina D en mujeres embarazadas con y sin diabetes gestacional. Ginecol Obstet Mex. 2018; 86 (10): 658-64. doi.10.24245/gom.v86i10.2262

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