Resumen

Se efectuó un estudio multicéntrico comparativo, aleatorio, seleccionando 170 pacientes de 18 años o más, con diagnóstico clínico de candidiasis genital y con cultivo positivo a Candida, los cuales se asignaron aleatoriamente al tratamiento con ciclopirox olamina en crema vaginal al 1% (85 pacientes) o con terconazol en crema vaginal al 0.8% (85 pacientes) durante seis días, con el objeto de comparar la eficacia clínica, la eficacia fungicida y la seguridad de ambos tratamientos.

Los resultados de la eficacia mixta (clínica y micológica) para ciclopirox olamina fue de cura al final del tratamiento - día siete - en 48 pacientes (62.3%) y al seguimiento - día 21 - de 42 (55.30%) y la mejoría al final en 25 pacientes (32.5%) y en el seguimiento 21 (27.6%) y para terconazol fue de cura al final en 45 pacientes (61.6%) y al seguimiento en 39 (57.4%) y de mejoría al final en 23 (31.5%) y en el seguimiento, 22 (32.4%). Se concluye que ambos medicamentos son eficaces y seguros para el tratamiento de candidiasis genital.

Palabras clave: Ciclopirox olamina, Terconazol, Candidiasis genital, Can­dida

Abstract

A multicenter randomized study was performed. One hundred and seventy patients were selected. The patients were 18 years and older. They presented signs and symptoms of genital candidiasis and had positive smear cuture for Candida. Eighty five patients were assigned to receive Cicloprox olamine 1%, and eighty five patients were asigned to receive Terconazol 0.8%. The treatment lasted six days with the objective to compare the clinical and antifungal efficiency and safety with both treatments. The result of mixed efficiency (clinical and microbiology) for Cicloprox olamine was 48 cases (62.3%) at the end of the treatment were cured -day 7-; and at the continuation -day 21-42 of them had the same result (55.3%); improvement was seen at the end in 25 cases (32.5%) and at the continuation 21 cases had the same result (27.6%). Far Terconazol the result was 45 cases (61.6%) were cured at the end of the treatment, and at the continuation 39 had the same result (57.4%); improvement was seen at the end in 23 cases (31.5%) and at the continuation 22 cases had the same result (32.4%). We conclude that both treatments are effective and well tolerated far genital candidiasis treatment.

Key words. Ciclopirox olamine, Terco­nazol, genital candidiasis, Candida